Tirzepatide programmes compared

Every programme on this page supplies tirzepatide, but they are not supplying the same thing. Some dispense a compounded preparation made by a pharmacy; one dispenses the manufacturer's own FDA-approved product. That difference matters more than the price gap.

Coreage Rx ranks first on our rubric. But before comparing any of these on cost, be clear which category you are buying from — we set that out in what "compounded" actually means.

The comparison

Prices verified 2026-09-18. "Per month" includes any membership billed alongside the medication.

1. Coreage Rx

What arrives is compounded tirzepatide — prepared by a pharmacy rather than manufactured by Eli Lilly — shipped with syringes and a dosing schedule. It is the same category of product sold by most of the low-cost programmes on this site. It is not Zepbound, and it is not FDA-approved. That distinction is explained properly in what compounded actually means, and it is the single most important thing to understand before you buy.

$199 a month. The $99 and $149 rates are annual-plan prices. If you want month-to-month, budget $149 and $199 instead, and check the refund terms before prepaying a year. Full review.

2. Trimi

Compounded tirzepatide, prepared per individual prescription by a state-licensed 503A pharmacy. Trimi states plainly on its own pages that compounded medication is not FDA-approved as a drug, and cites the SURMOUNT-1 and STEP-1 figures as trials of the active ingredients rather than of its own product. That is the correct way to describe it, and most of this market does not bother.

$125 a month. Both headline prices are annual-plan rates. Confirm the month-to-month figure and the refund terms before prepaying twelve months. Full review.

3. PlexusDx

Compounded tirzepatide from a state-licensed 503A pharmacy, typically delivered within five to seven business days. Because the pharmacies are named, you can look up their licensure yourself rather than taking a marketing page on trust — which is exactly what we tell readers to do.

$189 a month. The advertised "from $129" is the programme floor. Budget $189/month for the compounded injection tier. Full review.

4. Ozari Health

Compounded tirzepatide from licensed pharmacies. Ozari does not name which pharmacy or state whether it is 503A or 503B, which is the significant gap in an otherwise well-documented listing. Ask before you order.

$125 a month. Confirm whether $86 is a month-to-month rate or requires a longer commitment, and ask which pharmacy compounds it. Full review.

5. Fifty 410

Compounded tirzepatide from independent FDA-registered 503A pharmacies. Fifty 410 states plainly that it is a telehealth platform that does not compound, manufacture or distribute medication itself, and that compounded preparations are not FDA-approved finished drug products. It then goes further than most: published detail on USP 797 sterility standards, identity testing of raw materials, potency verification per batch, endotoxin testing for injectables, ISO Class 5-7 cleanrooms and batch record traceability.

$133 a month. The $133 is the starter protocol. Moving to the high-dose protocol takes it to $183/month, and both are prepaid three-month commitments. Full review.

6. Ivím Health

Compounded tirzepatide. Ivím does not publish which pharmacy compounds it or whether that pharmacy is 503A or 503B — the one significant gap in an otherwise well-documented programme. Ask before you start, and ask for it in writing.

$199 a month. Pharmacy sourcing is not published. Ask which pharmacy fills your prescription and whether it is 503A or 503B before starting. Full review.

7. Mochi Health

Compounded medication where cash-pay is the route, and covered branded prescriptions where the insurance work succeeds. That dual path is unusual and genuinely valuable: your supply is not tied to the compounding rules surviving.

$278 a month. Labs are billed separately. Ask what the clinic expects to order before you sign up. Full review.

8. Coby Health

Compounded tirzepatide with an at-home injection kit — alcohol pads and syringes — included in the price. The company also notes that product images are illustrative and the actual product will vary, which is the kind of small accuracy most marketing skips.

$239 a month. The $179 figure is a multi-month rate. Month-to-month is $239. Full review.

About tirzepatide itself

A single weekly injection that activates two gut hormone receptors, GIP and GLP-1, rather than one.

In SURMOUNT-1, adults with obesity lost an average of 19.5% of body weight on 10 mg and 20.9% on 15 mg over 72 weeks.

Doses step up through 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg. Common effects: Nausea, diarrhoea, constipation and reflux, concentrated in the weeks after each dose increase.

Full detail in tirzepatide explained.

Brand-name equivalents

Through LillyDirect self-pay, single-dose Zepbound vials at 5 mg, 7.5 mg and 10 mg have been listed at $499/month, with lower starting doses nearer $299-$349.

How we ranked these

• True monthly cost (30%) — What you actually pay in month two — medication plus membership plus anything billed separately. Advertised teaser rates score nothing here.
• Price honesty (20%) — Whether the renewal price is visible before you hand over a card, and whether the number at checkout matches the number in the ad.
• Clinical support (20%) — Who prescribes, how you reach them between visits, and whether dose changes are reviewed by a person or applied on a schedule.
• Pharmacy sourcing (15%) — Whether the provider names its pharmacy, states the 503A/503B pathway, and offers FDA-approved options alongside compounded ones.
• Cancelling (15%) — How hard it is to stop. Prepaid multi-month plans that cannot be refunded are marked down here.

Coreage Rx is our paid featured partner and sits first in this table; the rest follow in computed-score order. The scores themselves are untouched by the arrangement — how we rate publishes the unpinned order, and the commercial terms are on our disclosure page.