Comparison

Semaglutide programmes compared

17 programmes side by side — what each dispenses, under what authority, and what it really costs.

Updated 2026-09-18

Disclosure: one company on this page — Coreage Rx — pays us a commission when a reader signs up through our link. It does not buy a better score, a higher ranking, or the removal of any criticism. The scoring rubric and the full disclosure are both published.

Every programme on this page supplies semaglutide, but they are not supplying the same thing. Some dispense a compounded preparation made by a pharmacy; one dispenses the manufacturer's own FDA-approved product. That difference matters more than the price gap.

Coreage Rx ranks first on our rubric. But before comparing any of these on cost, be clear which category you are buying from — we set that out in what "compounded" actually means.

The comparison

Dispensed by	Product	Per month	Score
Coreage Rx Best overall on true monthly cost	Compounded	$149	4.5
Trimi Lowest flat price with named pharmacies	Compounded	$99	4.6
PlexusDx Pharmacy transparency and genetic testing	Compounded	$189	4.4
Ozari Health Lowest advertised semaglutide price	Compounded	$86	4.4
Ivím Health Unlimited clinician access	Compounded	$199	4
Mochi Health Insurance concierge support	Compounded	$178 +$79 fee	3.6
Coby Health Multi-month value with supplies included	Compounded	$229	3.6
Hims & Hers Widest range of formats	Compounded	$188 +$39 fee	3.5
Ro Branded medication with insurance help	FDA-approved brand	$448 +$149 fee	3.5
Zealthy Low-cost entry with insurance routing	Compounded	$151	3.5
LifeMD Insurance coordination	Compounded	$149	3.5
Noom Med Behaviour change alongside medication	Compounded	$149	3.5

Prices verified 2026-09-18. "Per month" includes any membership billed alongside the medication.

1. Coreage Rx

Compounded semaglutide, pharmacy-prepared, shipped with supplies. Not Wegovy, not Ozempic, and not reviewed by the FDA for safety, effectiveness or manufacturing quality. If that difference matters to you — and there are good reasons it might — Ro is the programme here that works exclusively with approved products.

$149 a month. The $99 and $149 rates are annual-plan prices. If you want month-to-month, budget $149 and $199 instead, and check the refund terms before prepaying a year. Full review.

2. Trimi

Compounded semaglutide prepared per prescription by VialsRx or GreenwichRx. Not Wegovy, not Ozempic, and not FDA-approved — Trimi says so itself rather than leaving the drug name to imply otherwise.

$99 a month. Both headline prices are annual-plan rates. Confirm the month-to-month figure and the refund terms before prepaying twelve months. Full review.

3. PlexusDx

Compounded semaglutide from a state-licensed pharmacy, with CLIA-certified labs behind the company’s testing line and SOC 2 and HIPAA claims on the platform. Not FDA-approved, as with every compounded preparation on this site.

$189 a month. The advertised "from $129" is the programme floor. Budget $189/month for the compounded injection tier. Full review.

4. Ozari Health

Compounded semaglutide from licensed pharmacies, specific pharmacy not published. Not Wegovy, not Ozempic, and not FDA-approved — which Ozari states itself rather than leaving the drug name to imply otherwise.

$86 a month. Confirm whether $86 is a month-to-month rate or requires a longer commitment, and ask which pharmacy compounds it. Full review.

5. Ivím Health

Compounded semaglutide, pharmacy not publicly named. That is the question to put to them before you order.

$199 a month. Pharmacy sourcing is not published. Ask which pharmacy fills your prescription and whether it is 503A or 503B before starting. Full review.

6. Mochi Health

Compounded semaglutide, or a covered branded prescription where the insurance team succeeds. Having both routes available matters in a year when the compounding framework is being actively rewritten.

$178 a month. Labs are billed separately. Ask what the clinic expects to order before you sign up. Full review.

7. Coby Health

Compounded semaglutide with an at-home injection kit included.

$229 a month. The $179 figure is a multi-month rate. Month-to-month is $239. Full review.

8. Hims & Hers

Oral semaglutide is absorbed very differently from an injection — it has strict instructions about taking it on an empty stomach with a small sip of water and waiting before eating or taking anything else. If nobody has explained that to you, the product will underperform. It is a real consideration that price tables never capture.

$188 a month. The advertised entry prices and the membership are separate charges. Add $39/month to whatever medication figure you were quoted. Full review.

About semaglutide itself

A weekly injection that activates the GLP-1 receptor, slowing stomach emptying and reducing appetite signalling.

In STEP-1, adults on 2.4 mg lost an average of about 14.9% of body weight over 68 weeks.

Doses step up through 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, 2.4 mg. Common effects: Nausea, vomiting, diarrhoea and constipation, usually worst in the first weeks and after dose increases.

Full detail in semaglutide explained.

Brand-name equivalents

Through NovoCare, Wegovy has been offered at $199/month for the first two fills through 31 December 2026, then $349/month for 0.25-2.4 mg doses. The oral form is listed between $149 and $299/month by dose.

Important. Compounded preparations are not FDA-approved. The agency has not reviewed them for safety, effectiveness or manufacturing quality in the way it reviewed the branded products. That is not a claim that they are unsafe — it is a statement about what regulatory review has and has not happened.

How we ranked these

True monthly cost (30%) — What you actually pay in month two — medication plus membership plus anything billed separately. Advertised teaser rates score nothing here.
Price honesty (20%) — Whether the renewal price is visible before you hand over a card, and whether the number at checkout matches the number in the ad.
Clinical support (20%) — Who prescribes, how you reach them between visits, and whether dose changes are reviewed by a person or applied on a schedule.
Pharmacy sourcing (15%) — Whether the provider names its pharmacy, states the 503A/503B pathway, and offers FDA-approved options alongside compounded ones.
Cancelling (15%) — How hard it is to stop. Prepaid multi-month plans that cannot be refunded are marked down here.

Coreage Rx is our paid featured partner and sits first in this table; the rest follow in computed-score order. The scores themselves are untouched by the arrangement — how we rate publishes the unpinned order, and the commercial terms are on our disclosure page.