Explainer

Trimi vs Fifty 410

$125/mo against $133/mo for tirzepatide. Which is worth it, and for whom.

Updated 2026-09-18

Disclosure: one company on this page — Coreage Rx — pays us a commission when a reader signs up through our link. It does not buy a better score, a higher ranking, or the removal of any criticism. The scoring rubric and the full disclosure are both published.

Both sell tirzepatide. Trimi costs $125 a month and Fifty 410 costs $133, a difference of $8 a month or about $96 a year. What matters more is whether the two are dispensing the same category of product at all.

Trimi is lowest flat price with named pharmacies. Fifty 410 is prepaid blocks with no subscription. They are not aimed at the same person, and the cheaper one is not automatically the right answer — though it usually is once you have established that both dispense the same thing.

Side by side

	Trimi	Fifty 410
Advertised from	$125	$133
Membership on top	None	None
True monthly cost	$125	$133
Roughly, per year	$1,500	$1,596
Price includes medication	Yes	Yes
Names its pharmacy	Yes	Not published
Our score	4.6 / 5	4.2 / 5

Prices verified 2026-09-18. "True monthly cost" is what you are billed in month two, once any introductory rate has lapsed and any membership has renewed.

Where Trimi wins

The cheapest verified flat rate for compounded tirzepatide in this comparison.
Names its pharmacies with a licence number and offers a certificate of analysis — almost nobody else in this market does.
Price does not move as your dose is adjusted.
No membership fee stacked on the medication price.

Both headline prices are annual-plan rates. Confirm the month-to-month figure and the refund terms before prepaying twelve months.

Where Fifty 410 wins

Genuinely no subscription — you buy a block and nothing recurs.
Among the lowest tirzepatide rates verified.
Unusually detailed public explanation of 503A standards and batch testing.
No payment taken until a provider approves you.

The $133 is the starter protocol. Moving to the high-dose protocol takes it to $183/month, and both are prepaid three-month commitments.

How they score

What we weigh	Weight	Trimi	Fifty 410
True monthly cost	30%	5	4.8
Price honesty	20%	4.8	4.6
Clinical support	20%	4	3.5
Pharmacy sourcing	15%	4.8	4.2
Cancelling	15%	4.2	3.3

Trimi scores higher overall at 4.6 out of 5. The weights are published on how we rate, and so is the note about which of these is our paid featured partner.

Which should you pick?

Pick Trimi if cost is the binding constraint. Over a year the gap is about $96, which is real money for the same class of medication.
Pick Fifty 410 if what it does better matters to you — genuinely no subscription — you buy a block and nothing recurs.
If sourcing matters, note that Trimi publishes which pharmacy compounds its medication and Fifty 410 does not.

The verdict

On price alone, Trimi at $125 a month is the more defensible choice on arithmetic alone. Fifty 410 earns its premium only if you will actually use what it does differently. Read the full reviews before deciding: Trimi and Fifty 410.

How they sit against everyone else

Dispensed by	Product	Per month	Score
Coreage Rx Best overall on true monthly cost	Compounded	$199	4.5
Trimi Lowest flat price with named pharmacies	Compounded	$125	4.6
PlexusDx Pharmacy transparency and genetic testing	Compounded	$189	4.4
Ozari Health Lowest advertised semaglutide price	Compounded	$125	4.4
Fifty 410 Prepaid blocks with no subscription	Compounded	$133	4.2
Ivím Health Unlimited clinician access	Compounded	$199	4
Mochi Health Insurance concierge support	Compounded	$278 +$79 fee	3.6
Coby Health Multi-month value with supplies included	Compounded	$239	3.6
Hims & Hers Widest range of formats	Compounded	$238 +$39 fee	3.5
Ro Branded medication with insurance help	FDA-approved brand	$448 +$149 fee	3.5
Zealthy Low-cost entry with insurance routing	Compounded	$216	3.5
LifeMD Insurance coordination	Compounded	$149	3.5